Monday Night Football in Week 16 features a battle between two playoff hopefuls in the San Francisco 49ers and Indianapolis Colts. All San Francisco has to do t

In order for the Colts to come away with a much-needed win, here are three keys to accomplishing that. The Colts' downfield passing game against Seattle was almost nonexistent with Phillip Rivers at quarterback. He had just two pass attempts of 20-plus yards as the Colts prioritized getting the ball out of his hands quickly.

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on Dec. 22. Who will win?

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

NFL.com's Bobby Kownack breaks down three must-know storylines ahead of Week 16's prime-time game between the San Francisco 49ers and Indianapolis Colts.

The Indianapolis Colts are dealing with another injury along the offensive line, early in their Monday Night matchup with the San Francisco 49ers. On the second play of the game, center Tanor Bortolini exited the game. He is being evaluated for a concussion.

IndyStar is expanding #AskJoel off X at halftime to the Indianapolis Colts ' entire game against the Jacksonville Jaguars here at IndyStar.com.

49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have officially put their playoff destiny in their own hands.