Murine mAbs were produced against purified microvillus membranes of rat colonocytes in order to establish a marker protein for this membrane. The majority of antibodies binding to the colonic ...

The human small intestine is an essential organ that helps us absorb nutrients and vitamins from food. It is an average of 6 meters long and is covered with millions of villi that are separated by ...

Crypt-base-columnar cells are continuously dividing intestinal stem cells that generate IECs, which are composed by distinct specialised cell types that play different functions: Enterocytes (in the ...

The inner lining of the gut regenerates entirely every four to seven days, thanks to stem cells in the intestinal epithelium. Yet much remains shrouded in mystery regarding stem cells and what causes ...

The study, “A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts,” was published in Immunity. The team, led by Carlene L. Zindl, Ph.D., found that IL-22 ...

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at ...

Scientists have uncovered a gut-specific epigenetic aging mechanism that links inflammation and iron imbalance to cancer risk ...

Although the gut renews itself constantly, its stem cells accumulate age-related molecular changes that quietly alter how ...

Researchers at the University of Gothenburg have now shown how mucus protects the small intestine in mice. In the future, this finding may lead to new ways of preventing relapse in Crohn’s disease in ...

As people live longer, the gut quietly accumulates damage that can tip the balance between healthy tissue renewal and chronic ...