Gene therapy with voretigene neparvovec-rzyl partially restores geniculostriate pathway function in LCA2 patients, improving visual processing. Initial LCA2 pathology shifts visual processing from the ...

New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...

Our brain is arguably the organ that most distinguishes humans from other primates. Its exceptional size, complexity and capabilities far exceed those of any other species on Earth. Yet humans share ...

Traditionally, cancer diagnosis and prognosis rely heavily on histopathological examination, where tissue morphology is evaluated under the microscope. However, the molecular ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...