This review is designed by Dr. Junhong Han and written by his postdoctoral researcher Dr. Lei Qiu and PhD student Qian Jing (Research Laboratory of Tumor Epigenetics and Genomics, West China Hospital, ...

Two new approaches could help scientists use existing sequencing technology to better-distinguish RNA changes that affect how their genetic code is read Kyoto University scientists are getting closer ...

Compared with eukaryotes, prokaryotes seem very efficient. Their genome is compact, usually consisting of a single chromosome. Most of the DNA encodes proteins. The information content of DNA is ...

RNA plays critical roles in nearly all biological processes, but current methods for sequencing RNA are significantly limited. This is partially because RNA molecules are chemically modified within ...

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message, or mRNA, which is then converted into protein. Although DNA remains the same ...

This is a preview. Log in through your library . Abstract N⁶-methyladenosine (m⁶A) is the most abundant internal messenger RNA (mRNA) modification, contributing to the processing, stability, and ...

The human body has to protect itself from pathogens and infectious agents, and there are a variety of ways for the immune system to sense foreign invaders, and react to the threats they may pose. But ...

After a gene is transcribed into RNA, modifications can occur to the subunits or "bases" that make up the RNA molecule, which can affect its structure and function. The study of these changes is known ...

A chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate is now confirmed to be key to the virus's ability to survive and thrive after infecting host cells ...

A team of researchers has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain. A team of researchers at ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...