Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

Example of super-resolution microscopy: The image shows how the Discrete Molecular Imaging (DMI) technology visualizes densely packed individual targets that are just 5 nanometer apart from each other ...

A decade ago, the Nobel Prize in Chemistry was awarded to a trio of researchers for the development of super-resolved fluorescence microscopy. The announcement at the time stated that the researchers’ ...

With the rapid revolution in super-resolution microscopy, the resolution of far-field optical microscopy has entered the sub-nanometer era, providing new insights into macromolecules in vitro and in ...

Microscopy involves the study of organisms too small to see with the naked eye, magnifying the small worlds within our own so we can study and understand these samples. Organs, tissues and cells, all ...

Fluorescence images of nuclei in a cell spheroid labeled by rsGamillus-S with a diameter of 100 µm observed with widefield, SPA-SIM, and 3DSIM at a depth of 43 µm. Credit: From Nature Methods (2024).

What is Photoactivated Localization Microscopy? Photoactivated Localization Microscopy (PALM) is a super-resolution imaging technique that allows for the visualization of biological structures at the ...

Images created with the new FLASH-PAINT microscopy technique, developed at Yale by the laboratory of Joerg Bewersdorf, PhD. Credit: Bewersdorf Laboratory, Yale University Images created with the new ...

In a study published in Science Advances, a team of bioengineering researchers at the University of Illinois Urbana-Champaign developed an algorithm known as adaptive intersection maximization, or AIM ...