CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

A new study shows, for the first time, how the human genome folds and moves in 3D over time to control when genes turn on and ...

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

These sequences are extremely prone to mutations and rank among the most functionally important regions in the entire human ...

In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators and the 4D Nucleome Project have unveiled the most detailed maps to date ...

New 3D genome maps reveal how DNA folding controls gene activity, offering fresh clues into disease and cell function.

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

These genes are part of the non-coding genome, which makes up about 98% of our DNA and was long dismissed as “junk.” This new research adds to growing evidence that this vast genetic landscape plays a ...

A groundbreaking genetic study has revealed that Italians who reach 100 carry significantly more ancient Western hunter-gatherer DNA than their younger counterparts. The research, published in ...

AlphaFold didn't accelerate biology by running faster experiments. It changed the engineering assumptions behind protein ...

It's a common storytelling trope: the stubborn foe who is eventually revealed to be a much-needed friend. Biology has its own ...

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce ...