A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

With Houston's win over the LA Chargers on Saturday, the Colts were officially eliminated from playoff contention. They are one of just a handful of teams in NFL history to start a season 8-2 and miss the postseason. As running back Jonathan Taylor described, when plays had to be made, the Colts often failed to come through.

Seattle Seahawks nose tackle Jarran Reed beats his blocker and meets Indianapolis Colts running back Jonathan Taylor in the backfield for a 3-yard loss in Week 15 at Lumen Field. Seattle Seahawks quarterback Sam Darnold connects with wide receiver Cooper Kupp on a 16-yard catch in the first half of Sunday's game against the Indianapolis Colts.

Watch the best plays from Green Bay Packers quarterback Malik Willis' 348-yard, three-touchdown game against the Baltimore Ravens in Week 17 of the 2025 NFL season. Watch the best plays from Baltimore Ravens running back Derrick Henry's 216-yard, four-touchdown game against the Green Bay Packers in Week 17 of the 2025 NFL season.

The Jacksonville Jaguars improved to 12-4 after defeating the Indianapolis Colts 23-17 on the road. Next up for Jax? A shot at the AFC South title.