In human cell models, small extracellular vesicles from senescent and older donor-derived cells reduced proliferation and ...

Aging is a complex biological process characterized by the progressive decline of physiological integrity, leading to impaired function and increased vulnerability to disease. It is the strongest risk ...

A new review in Discover Aging examines how the AP2A1 protein, long known for its role in clathrin-mediated endocytosis, has ...

Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in part, by failed macrophage-mediated ...

Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively kill these cells or inhibit the secretion of substances is ongoing. The latest ...

Please provide your email address to receive an email when new articles are posted on . More research is needed to understand aging, frailty and sarcopenia in rheumatology. GLP-1 receptor agonists may ...

A study links RUNX2 mutations in cleidocranial dysplasia to delayed tooth eruption through suppressed dental follicle cell ...

A team at Kumamoto University has made a discovery that could help promote healthy aging. As the world's population ages, Japan's aging population in particular is growing at an unprecedented rate, ...

What if a process we associate with aging actually helps the body heal? A study led by Mikolaj Ogrodnik, LBI Trauma, published in Nature Cell Biology, shows that cells enter a state of senescence ...

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer proliferate.