Jonathan Taylor stats, rushing yards and touchdowns against the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football.'

A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

Taylor rushed the ball 21 times for 70 yards and a touchdown in Sunday's 23-17 loss to the Jaguars. He added three receptions on six targets for 14 yards.

Watch the best plays from Green Bay Packers quarterback Malik Willis' 348-yard, three-touchdown game against the Baltimore Ravens in Week 17 of the 2025 NFL season. Watch the best plays from Baltimore Ravens running back Derrick Henry's 216-yard, four-touchdown game against the Green Bay Packers in Week 17 of the 2025 NFL season.

Jonathan Taylor tops 100 yards from scrimmage but he doesn't find the end zone as the Indianapolis Colts fall to the Houston Texans 20-13. Coming into the game, Taylor led the league with 1,197 rushing yards, and 15 rushing and 17 total TDs. His has 3 ...

The Jacksonville Jaguars play the Indianapolis Colts in Week 17 of the 2025 NFL season. Who wins? See our predictions and picks, plus game odds.